What is the active ingredient in daktarin? Daktarin cream contains the active substance: miconazole nitrate. Daktarin Aktiv cream is suitable for athlete’s foot which is often accompanied by sore, cracked skin. It has a Aktiv, anti-fungal/anti-bacterial agent that fights the infection. Signs and symptoms of athlete’s foot often include: Cracking and peeling of skin between the toes. How to use daktarin Aktiv Daktarin Aktiv cream should be applied to the affected area(s) of skin twice a day (morning and evening). Rub the cream gently into the affected area and surrounding skin. Wash your hands after applying the cream to avoid spreading the infection to other areas of the body, or to other people.